Antioxidant packaging with encapsulated green tea for fresh minced meat

A novel approach to incorporate green tea extract into polyethylene by extrusion technology has been studied. Green tea entrapped by inorganic capsules was incorporated into melted material and extruded without compromising its quality. The shelf-life of fresh meat from two types of active packaging was significantly extended for 3 0.25 days compared to blank samples. Significant difference was observed after 9th day of study in case of results of CIE L*a*b*, MetMb and organoleptic assay. Migration study of antioxidants from the materials was also performed by UHPLC-MS/TQ using food simulants. Amount of migrated catechins was in the range between 6.3 0.25 ± 0.25 3.3 and 228.4 0.25 ± 0.25 15.2 0.25 µg/kg (ratio 6:1). Regression coefficients (R) between 0.9925 and 0.9989 were obtained. Minimum LOD (0.001 0.25 µg/g) and LOQ (0.004 0.25 µg/g) were obtained for epicatechin gallate and catechin gallate while maximum LOD (0.057 0.25 µg/g) and LOQ (0.191 0.25 µg/g) were obtained for catechin

Application of untargeted metabolomics to determine volatile compounds from the Spanish plant Arctostaphylos uva-ursi used as tea

One-hundred and seven different volatile compounds were identified in the samples of Arctostaphylos uva-ursi collected from nine locations in Spain. This plant is commonly brewed and used as tea. Volatile compounds profile was detected using solid-phase microextraction gas chromatography-mass spectrometry. The most interesting compounds detected from an antioxidant capacity point of view were esters, phenols, and aromatics compounds. All samples were discriminated by principal component analysis. The insolation and altitude of harvest areas, and latent structures were considered for interpretation of results. Discriminant analysis was applied to control the type and concentration of metabolites and determine the best plant antioxidant profiles of volatile compounds from plant origin. Moreover, a heatmap displayed correlations between detected compounds. The discriminant analysis led to 20 quality markers being identified for the analysed plants. The strongest antioxidant capacity was obtained in the samples from Pina de Montalgrao and Loarre (collected in September) for ORAC (33.11 ± 0.61 g Trolox/g sample) and DPPH (IC50 = 711 ± 12 µg/g) methods, respectively. The plant with the highest total phenolic content was Loarre collected in September (171.9 ± 19.4 mg GAE/g DW) and November (177.1 ± 11.0 mg GAE/g DW)

Ultra-high performance liquid chromatography coupled to ion mobility quadrupole time-of-flight mass spectrometry for the identification of non-volatile compounds migrating from ´natural´ dishes

Although most new biomaterials for food industry applications are labelled ‘100% natural fabrication’ and ‘chemical-free’, certain compounds may migrate from those materials to the food, compromis- ing the organoleptic characteristics and safety of the product. In this work, the degree of compound migration from dishes made with four different biomaterials: bamboo, palm leaf, wood and wheat pulp was investigated. Migration tests were carried out using three food simulants, 10% ethanol (sim- ulant A), 3% acetic acid (simulant B), and 95% ethanol (simulant D2). Unequivocal identification of non-intentionally added substances (NIAS) is challenging even when using high-resolution mass spectrometry techniques however, a total of 25 different non-volatile compounds from the migration tests were identified and quantified using Ultra-high performance liquid chromatography coupled to ion mobility quadrupole time-of-flight mass spectrometry (UPLC-IMS-MS). In the bamboo samples three oligomers, cyclic diethylene glycol adipate, 3,6,9,16,19,22-hexaoxabicyclo[22.3.1]-octacosa-1(28),24,26- triene-2,10,15,23-tetrone and 1,4,7,14,17,20-hexaoxacyclohexacosane-8,13,21,26-tetrone exceeded the specified limits of migration

Antioxidant activity of coatings containing eugenol for flexible aluminium foils to preserve food shelf-life

Active food packaging is an innovative system that avoids food deterioration ensuring quality, safety and shelf-life extension of food. Herein, two novel eugenol vinyl-based resins were used for coating flexible aluminium foils with potential packaging applications. Coatings were prepared with single eugenol or loaded eugenol in Santa Barbara Amorphous15 (SBA-15) mesoporous silica nanoparticles, and their antioxidant activity was investigated by DPPH, ABTS, ORAC, TBARS assays and by the hydroxyl free radicals’ generator method with HPLC analysis. Antioxidant activity was also evaluated exposing the coatings to various food simulants. Both coatings revealed adequate antioxidant capacity when exposed to fatty food simulants and to vapour phase hydroxyl free radicals (scavenging > 50%). The incorporation of eugenol in SBA-15 reduced its release to 65%, promoting eugenol beneficial antioxidant effects over time. The release of eugenol from the coatings into food simulants is not required for the activity of free radical scavenging

Volatile Compounds and Off-odors Analysis of PLA from Recycling Cycle for Biodegradable Packaging Applications: An Essential Factor for Ensuring Food Safety and Quality

Recent European guidelines support the use of recycled and biodegradable packaging for food applications that involve single-use materials. In this work, PLA pellets were submitted to post-consumer recycling cycle industry. HS-SPME-GC-MS and HS-SPME-GC-O-MS methods have been used to detect hazardous volatile compounds and off-ofors profiles.Recent European guidelines support the use of recycled and biodegradable packaging for food applications that involve single-use materials. In this work, PLA pellets were submitted to post-consumer recycling cycle industry. HS-SPME-GC-MS and HS-SPME-GC-O-MS methods have been used to detect hazardous volatile compounds and off-ofors profiles

Development of innovative antioxidant food packaging systems based on natural extracts from food industry waste and Moringa oleifera leaves

Active packaging that prolongs food shelf life, maintaining its quality and safety, is an increasing industrial demand, especially if integrated in a circular economy model. In this study, the fabrication and characterization of sustainable cellulose-based active packaging using food-industry waste and natural extracts as antioxidant agents was assessed. Grape marc, olive pomace and moringa leaf extracts obtained by supercritical fluid, antisolvent and maceration extraction in different solvents were compared for their antioxidant power and phenolic content. Grape and moringa macerates in acetone and methanol, as the most efficient and cost-effective extracts, were incorporated in the packaging as coatings or in-between layers. Both systems showed significant free-radical protection in vitro (antioxidant power 50%) and more than 50% prevention of ground beef lipid peroxidation over 16 days by indirect TBARS and direct in situ Raman microspectroscopy measurements. Therefore, these systems are promising for industrial applications and more sustainable farm-to-fork food production systems

New active packaging based on encapsulated carvacrol, with emphasis on its odour masking strategies

New active polyethylene packaging with both antioxidant and antimicrobial properties was designed and produced using three different concentrations of encapsulated carvacrol. Films containing 10%, 20% and 30% of active capsules showed strong antioxidant activity as hydroxyl (OH·) radical scavengers, while only films containing 30% capsules showed anti-Salmonella enterica activity. Storage of active packaging rolls in sealed aluminium bags maintained both the antioxidant and antimicrobial properties of the films for up to 9 months. Two strategies were used to control or eliminate the strong odour of the developed packaging materials: odour masking spray and multilayer packaging. Migration tests were carried out to assess the safety of packaging. The most successful strategy was the development of two active multilayer packaging materials (polyethylene terephthalate (PET)/adhesive/active low density polyethylene (LDPE) with 10% capsules and aluminium/adhesive/active LDPE with 10% capsules) which reduced the oxidation of packaged crisps stored at 60 °C for 30 days by up to 45%, measured as malonaldehyde using the TBARS assay. In addition, the packaging materials did not affect the organoleptic properties of the stored crisps as determined by sensory analysis. These results show that this novel bifunctional (antioxidant and antimicrobial) active packaging can protect fatty foods from oxidation processes while preserving their organoleptic properties

Effectiveness of osimertinib in patients with lung adenocarcinoma in clinical practice — the Expanded Drug Access Program in Poland

Introduction: Osimertinib is a third-generation, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that has demonstrated efficacy in the treatment of EGFR-mutant non-small-cell lung cancer (NSCLC) in prospective clinical trials. Material and methods: This retrospective analysis evaluated the outcomes of 32 pretreated patients with EGFR T790M mutation who received osimertinib in clinical practice at seven centers in Poland within the Expanded Drug Access Program. Osimertinib was used in the second line in 59% of patients and in later lines in 41%. Results: Objective response was attained in 16 patients (50%), and 12 subjects (38%) had stable disease. Median progression -free survival was 11.3 months in the overall population, 12.6 months in patients with EGFR exon 19 mutation and 7.5 months in patients with EGFR exon 21 mutation (p = 0.045). Median overall survival (OS) was 18.3 months. Overall, 58.4% and 45.6% of patients remained in follow-up after 12 and 24 months, respectively. Median OS appeared longer for patients without cerebral metastases than for those with cerebral metastases (27.4 vs 9.4 months, respectively; p = 0.078), and for patients with the Eastern Cooperative Oncology Group performance status (ECOG PS) 0–1 than those with ECOG PS 2 (27.4 vs 11.8 months, respectively; p = 0.189), although neither result reached statistical significance. Median OS of patients with partial response, stable disease and progressive disease was 27.4, 12.7 and 4.5 months, respectively (p < 0.001). Age, comorbidities, line of treatment with osimertinib, and type of activating EGFR mutation did not impact on OS. Adverse events of any grade or grade 3/4 were reported in 38% and 9% of patients, respectively. One person discontinued due to interstitial pneumonia.Conclusion: These results confirm the value of osimertinib in patients with previously treated EGFR T790M-mutant NSCLC. Clinical benefit was evident in patients with cerebral metastases and moderate performance status

Zamki i pałace Śląska : dziedzictwo - tożsamość - arystokracja

Prezentowana książka jest wynikiem obrad konferencyjnych, które miały miejsce w dniach 19-20 marca 2012 roku. Konferencja naukowa „Zamki i pałace Śląska”, której organizatorami byli: Muzeum Zamkowe w Pszczynie, Zakład Historii Sztuki Uniwersytetu Śląskiego w Katowicach oraz działające w tymże Zakładzie Studenckie Koło Naukowe Historyków Sztuki,Paweł Ziegler - Wprowadzenie ; Marta Ostrowska-Bies - Nie tylko Paulinum : historia współpracy architekta Karla Grossera i jego zleceniodawcy, Oscara Caro ; Wioletta Wrona-Gaj - Arystokrata a siedziba rodowa. Wpływ zainteresowań i pozycji przedstawicieli rodu Hochbergów i Schaffgotschów na kształtowanie architektury rezydencjonalnej ; Hanna Górska - Dwory i pałace o drewnianej konstrukcji szkieletowej na Śląsku ; Aneta Borowik - Forma architektoniczna Pałacu Młodzieży im. prof. Aleksandra Kamińskiego w Katowicach oraz materiały źródłowe do konkursu z 1948 roku ; Magdalena Marzec - Formy neorenesansu francuskiego w nieistniejącym już Małym Wersalu w Świerklańcu ; Maria Pallado - O stylu neomauretańskim na przykładzie sali mauretańskiej pałacu w Krowiarkach ; Justyna Dziembała, Sabina Rotowska - Pałac Goldsteinów wczoraj i dziś. Historia i prace konserwatorskie obiektu ; Daria Rzepiela - Przeszłość w przyszłości – teoretyczne rozważania projektowe dotyczące Pałacu w Dobrej ; Agata Stronciwilk, Miłosz Markiewicz - Mit – manipulacja : tożsamość. Portrety historyzujące z Pałacu w Pławniowicach i Domu Kawalera w Świerklańcu ; Helena Jadwiszczok-Molencka - Medialny obraz powojennych losów fundacji Tiele-Wincklerów w Miechowicach.Agnieszka Uziębł

Neurological symptoms in hospitalised patients with COVID-19 and their association with in-hospital mortality

Objectives. To evaluate the spectrum of neurological symptoms in patients with COVID-19 during the first 14 days of hospitalisation and its association with in-hospital mortality. Material and methods. We included 200 patients with RT-PCR-confirmed COVID-19 admitted to University Hospital in Krakow, Poland. In 164 patients, a detailed questionnaire concerning neurological symptoms and signs was performed prospectively within 14 days of hospitalisation. In the remaining 36 patients, such questionnaires were completed retrospectively based on daily observations in the Department of Neurology. Results. During hospitalisation, 169 patients (84.5%) experienced neurological symptoms; the most common were: fatigue (62.5%), decreased mood (45.5%), myalgia (43.5%), and muscle weakness (42.5%). Patients who died during hospitalisation compared to the remainder were older (79 [70.5–88.5] vs. 63.5 [51–77] years, p = 0.001), and more often had decreased level of consciousness (50.0% vs. 9.3%, p < 0.001), delirium (33.3% vs. 4.4%, p < 0.001), arterial hypotension (50.0% vs. 19.6%, p = 0.005) or stroke during (18.8% vs. 3.3%, p = 0.026) or before hospitalisation (50.0% vs. 7.1, p < 0.001), whereas those who survived more often suffered from headache (42.1% vs. 0%, p = 0.012) or decreased mood (51.7% vs. 0%, p = 0.003). Conclusions. Most hospitalised patients with COVID-19 experience neurological symptoms. Decreased level of consciousness, delirium, arterial hypotension, and stroke during or before hospitalisation increase the risk of in-hospital mortality